Tesamorelin Dosage
Tesamorelin is typically used at
2 mg daily (subcutaneous injection) for HIV-associated lipodystrophy, with off-label use for fat loss at similar or slightly lower doses (1–2 mg daily). Since you’re new to tesamorelin and combining it with tirzepatide, starting at a lower dose is prudent to assess tolerance, especially given the potential for glucose metabolism interactions (noted in a Drugs.com moderate interaction warning).
- Recommended Starting Dose: Begin with 1 mg daily for 4–8 weeks to monitor side effects (e.g., injection site reactions, joint pain, or glucose changes due to elevated IGF-1). If tolerated, increase to 2 mg daily, the standard therapeutic dose for fat loss, as seen in studies showing 15–20% visceral fat reduction over 26 weeks.
- What to Order: Tesamorelin is supplied as lyophilized powder in 2 mg or 5 mg vials, reconstituted with 1–2 mL bacteriostatic water per vial. For a 30-day supply:
- At 1 mg/day: Order 30 mg total (e.g., 30 x 1 mg vials or 15 x 2 mg vials). Each 1 mg vial reconstituted with 1 mL yields 1 mg/mL, so you’d draw 1 mL daily.
- At 2 mg/day: Order 60 mg total (e.g., 60 x 1 mg vials or 30 x 2 mg vials). For a 2 mg vial reconstituted with 1 mL, you’d draw 1 mL to get 2 mg daily.
- Recommendation: Start with 30 x 1 mg vials (30 mg total) for a 1 mg/day dose for 30 days. If you titrate to 2 mg/day, you’d need to double the order (60 x 1 mg or 30 x 2 mg vials). Include 30–60 mL bacteriostatic water for reconstitution (1 mL per vial) and insulin syringes (31-gauge, 1 mL).
- Considerations: Tesamorelin is unstable after reconstitution, so reconstitute only what you’ll use immediately (daily). Store lyophilized vials at room temperature or refrigerated (2–8°C).
Hope it helps.