A Comparative Overview, Suggested Combinations & Dosage Guidelines
Understanding how different peptides interact in muscle growth and recovery research can help structure more efficient experimental protocols. Below is a breakdown of three commonly studied peptides: IGF-1 LR3, GHRP family, and CJC-1295, including suggested dosage ranges for laboratory research.
IGF-1 LR3
Function:
A stable and long-acting analog of IGF-1. Commonly studied for its role in muscle cell regeneration, hypertrophy, and post-stimulation recovery.
Research Highlights:
- Extended biological activity (20–30 hours)
- Independent of GH stimulation
- Applied post-GH stimulation for better synergy
Suggested Research Dosage:
- 20–50 mcg per day
- Administered once daily, typically post-exercise model or in split protocols
GHRP Family
Function:
Stimulates the pituitary to release growth hormone by activating the ghrelin receptor. Different analogs offer distinct properties.
Variants & Notes:
- GHRP-2 – Potent GH stimulator with mild hunger effect
- GHRP-6 – Stronger appetite stimulation, suitable for bulking models
- Ipamorelin – Clean GH stimulation, minimal side effects, ideal for sensitive protocols
Suggested Research Dosage:
- GHRP-2 / GHRP-6: 100–300 mcg per administration, 1–3 times per day
- Ipamorelin: 100–300 mcg per dose, typically 2 times per day
CJC-1295
Function:
A synthetic GHRH analog that supports long-term GH release. Frequently used with GHRPs to maximize GH pulsatility.
Forms:
- With DAC: Sustained release over 5–7 days
- Without DAC: Shorter duration, ideal for controlled timing protocols
Suggested Research Dosage:
- With DAC: 1–2 mg per week, divided or single dose
- Without DAC: 100–200 mcg per administration, typically 1–2 times per day
Suggested Research Combinations
1. CJC-1295 (No DAC) + GHRP-2 or Ipamorelin
→ Mimics natural GH pulsation; often dosed 1–3 times daily for rhythm modeling.
2. IGF-1 LR3 Alone
→ Typically applied after GH stimulation protocols to study cellular response to IGF pathways.
3. Full Stack: CJC-1295 + GHRP + IGF-1 LR3
→ Synergistic approach combining GH axis stimulation with direct IGF-1 cellular action.
Final Notes
Each compound supports different pathways:
- GHRPs stimulate GH naturally
- CJC-1295 sustains or amplifies GH pulses
- IGF-1 LR3 promotes post-GH muscle growth and cellular activity
For well-structured experiments, consistent timing, controlled dosing, and environmental stability are key to reproducible results.
Research use only. Not intended for human or veterinary use. Follow all applicable regulations and institutional standards.